Alex Oxlade-Chamberlain and Mathieu Debuchy (both hamstring) and captain Mikel Arteta (ankle) are in contention after returning to training.
Shay Given is fit for Aston Villa's first Cup final in 15 years after recovering from a groin injury.
Aly Cissokho (groin), Kieran Richardson (calf) and Jores Okore (knee) have also trained but Ciaran Clark (knee) is out.
Arsenal midfielder Aaron Ramsey scored an extra-time winner last season as they beat Hull 3-2 to win their first trophy in nine years.
And the Welshman is hopeful of adding another trophy to his collection as Arsenal look to become the first team to retain the Cup since Chelsea in 2010.
Ramsey said: "To score a winner in the FA Cup final, it's everybody's dream and I managed to live it.
"To finally win something after all those years and the pressure that has been put on this club was such a nice feeling of relief to finally win something.
"We never do it easy. We've experienced what it's like now, going a few goals behind early in the game, but we still believed in ourselves and our ability to get through it.
"Hopefully it will be a bit easier this time and we won't have to put so many people through that.
"Villa are a good team, very solid and of late they've been in really good form, so we'll have to be aware of that."
Villa could have Christian Benteke available for the last time, as speculation continues to link him with a summer move.
But manager Tim Sherwood is confident of keeping Benteke, and teenage midfielder Jack Grealish, who could start after impressing in the semi-final win over Liverpool.
"Grealish has coped with the pressure up until now, when he is asked to step up he has ticked the boxes," he said.
"The bigger the stage, the better he's been. There isn't any bigger stage than this one, so I'm hoping he performs - otherwise we'll sell him!
"He is great, he loves playing. I don't think he gets nervous. He doesn't look the type. He's a terrific player and we're happy he's on our side.
"I think he realises it because he is around Aston Villa fans - Jack has never seen the club win a trophy.
"Even if he tries to get away from it, it's impossible with his family walking around with Villa shirts on every day."
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